严雪龙
2024-05-22 11:07  


     严雪龙,博士,副教授,青年博士生导师。

     研究方向

                          生药学、天然药物化学

      药食两用中药产品研发

     联系方式:

      电话 15250968467

      电子邮件:yanxlong54@163.com

简介

主要研究方向为药用植物活性天然产物的挖掘、结构修饰、药效与作用机制、药食两用产品研发2009-2016在中国药科大学中耀世注册本硕连读,分别获中药学学士及中药资源学硕士学位。20206月毕业于中山大学耀世注册,获生药学专业博士学位。20207-20229月在耀世主管官网基础医学博士后科研流动站开展博士后研究,20209月出站后留校工作。迄今,在Journal of the American Chemical SocietyActa Pharmaceutica Sinica BJournal of Medicinal ChemistryOrganic LettersBioorganic Chemistry等国际期刊上发表通讯及第一作者论文14篇。

经历

2020/10至今   耀世主管官网耀世注册,副教授青年博士生导师

2020/08—2022/09 耀世主管官网基础医学博士后科研流动站博士后研究员

2016/09—2020/06 中山大学耀世注册生药学、博士

2013/09—2016/07 中国药科大学中药资源学硕士

2009/09—2013/07 中国药科大学中药学,学士

教学情况

1. 生药学

2. 中药鉴定学

3. 药用植物学

科研项目

1.国家自然科学基金,22167009:抗肥胖症瑞香烷型二萜小分子探针的构建及其靶点识别,35万元,主持,2022. 01-2025. 12

2. 中国博士后科学基金,2021M693809:中药黄芫花中抗肥胖症瑞香烷型二萜的发现、结构修饰及构效关系研究,8万元,主持,已结题。

3. 贵州省科技厅基础研究计划重点项目,黔科合基础-ZK[2024]重点037:基于importin-b1为靶点抗去势抵抗性前列腺癌瑞香烷型二萜先导物的发现、构效关系及初步成药性研究,30万元,主持,2024.04~2028-04

论著专利

(1) Xue-Long Yan, Yue-Hua Pan, Run-Zhu Fan, Qin-Qin Song, Shen Li, Jia-Luo Huang, Wei Li, Dong Huang, Fang-Yu Yuan, Gui-Hua Tang, Yong Rao,* Zhi-Shu Huang, and Sheng Yin*. Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent. Journal of Medicinal Chemistry, 2023, 66, 5839−5858. (中科院1top, IF 8.039).

(2) Xue-Long Yan, Jun Sang, Shi-Xin Chen, Wei Li, Gui-Hua Tang, Li-She Gan, and Sheng Yin*. Euphorkanlide A, a Highly Modifified Ingenane Diterpenoid with a C24

Appendage from Euphorbia kansuensis. Organic Letters, 2019, 21, 4128−4131. (中科院1top, IF 6.072)

(3) Jia-Luo Huang,# Xue-Long Yan,# Wei Li, Run-Zhu Fan, Shen Li, Jianghe Chen, Zhenhua Zhang, Jun Sang, Lu Gan, Gui-Hua Tang, Hongwu Chen, Junjian Wang,* and Sheng Yin*, Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. Journal of the American Chemical Society, 2022, 144, 17522−17532. (共同一作,中科院1TopIF 16.383)

(4) Jia-Luo Huang,# Xue-Long Yan,# Dong Huang, Lu Gan, Huahua Gao, Run-Zhu Fan, Shen Li, Fang-Yu Yuan, Xinying Zhu, Gui-Hua Tang, Hong-Wu Chen, Junjian Wang,* Sheng Yin*. Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer. Acta Pharmaceutica Sinica B, 2023, 13(12), 4934-4944. (共同一作,中科院1TopIF 14.5)

(5) Shen Li, Lu Gan, Yi-Jing Tian, Yang Tian, Run-Zhu Fan, Dong Huang, Fang-Yu Yuan, Xu Zhang, Yan Lin, Qin-Feng Zhu, Gui-Hua Tang, Xue-Long Yan,* Sheng Yin*. Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway. Bioorganic Chemistry, 2021, 114, 105222. (中科院1区,IF 5.307)

(6) Xue-Long Yan, Jun-Sheng Zhang, Jia-Luo Huang, Yao Zhang, Jia-Qi Chen, Gui-Hua Tang, Sheng Yin*. Euphonoids A−G, cytotoxic diterpenoids from Euphorbia fischeriana. Phytochemistry, 2019, 166, 112064. (中科院2, IF 4.004).

(7) Xue-Long Yan, Bei-Ling Chen, Fang-Yu Yuan, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Shang-Gao Liao*. Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis. Arabian Journal of Chemistry, 2022, 15, 103807. (中科院2区,IF 6.212)

(8) Xue-Long Yan, Ming-Feng Zou, Bei-Ling Chen, Fang-Yu Yuan, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Wu-Ling Liu*, Shang-Gao Liao*. Euphorane C, an unusual C17-norabietane diterpenoid from Euphorbia dracunculoides induces cell cycle arrest and apoptosis in human leukemia K562 cells. Arabian Journal of Chemistry, 2022, 15, 104203. (中科院2区,IF 6.212).

(9) Xue-Long Yan, Jun-Sang, Xu Zhang, Yan Lin, Qing-De Long, Qin-Feng Zhu, Shang-Gao Liao*. Euphorboside A, a cytotoxic meroterpenoid glycoside with an unusual humulene-phloroglucinol skeleton from Euphorbia kansuensis. Fitoterapia, 2021, 153, 104966. (中科院3区,IF 3.204).

(10) Bei-Ling Chen, Qin-Feng Zhu, Xu Zhang, Yan Lin, Qing-De Long, Wu-Ling Liu*, Xue-Long Yan*. An unusual indole-diterpenoid with C-17 norcassane skeleton from Euphorbia fischeriana induces HEL cell cycle arrest and apoptosis. Fitoterapia, 2022, 159, 105195. (中科院3区,IF 3.204).


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